Histamine H3-receptors· in the central nervous system of rats and mice
نویسنده
چکیده
We describe the binding of [125I]iodophenpropit, the first radiolabelled histamine H3-antagonist, to ratcortex membranes. The binding of [125I]iodophenpropit was selective, saturable, readily reversible, and of high affinity (Ko-value of 0.32 nM; Bmax-value of 209 fmoVmg of protein). Specific binding at a concentration of 0.3 nM accounted for 45 to 55% of total binding. [125I]Iodophenpropit is a promising ligand for H3-receptor binding studies. *Rephartox B.V., Maarssen, The Netherlands.
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